SCHEMBL1976765

SCHEMBL1976765

COC(=O)[C@@H]1CCCN1C(=O)OCCl

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.50
RAB9A P51151 2/20 0.49
FKBP1A P62942 6/20 0.48
PEPD P12955 2/20 0.45
ALDH1A1 P00352 2/20 0.44
XPNPEP1 Q9NQW7 1/20 0.42
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PKM P14618 1/20 0.41
ALOX5 P09917 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
PREP P48147 1/20 0.39
CNR2 P34972 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23217918 0.90 RAB9A (0.50) POLBRAB9AFKBP1AALDH1A1SMN1; SMN2
SCHEMBL20351263 0.89 RAB9A (0.47) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL20351315 0.89 RAB9A (0.47) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL3009794 0.87 FKBP1A (0.54) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL3009795 0.87 FKBP1A (0.54) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL5499151 0.87 FKBP1A (0.54) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL3231642 0.84 FKBP1A (0.51) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL20123372 0.84 POLB (0.50) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL9546469 0.83 POLB (0.58) POLBRAB9AFKBP1APEPDALDH1A1
SCHEMBL30599979 0.83 POLB (0.58) POLBRAB9AFKBP1APEPDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215030-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. 2025-07-03 US disclosed
US-20250179103-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS RECLUDIX PHARMA, INC. 2025-06-05 US disclosed
EP-4499656-A1 STAT MODULATORS AND USES THEREOF Recludix Pharma, Inc. (US) 2025-02-05 EP disclosed
CN-119301127-A 6-Oxo-decahydro pyrrolo [1,2-a ] [1,5] diazocine and 6-oxo-decahydro-4H-pyrrolo [2,1-d ] [1,5] thiaazacine derivatives as modulators of STAT3 and STAT6 for the treatment of cancer and inflammatory conditions 瑞克鲁迪克斯制药股份有限公司 2025-01-10 CN disclosed
CN-119183453-A STAT modulators and uses thereof 瑞克鲁迪克斯制药股份有限公司 2024-12-24 CN disclosed
WO-2023192960-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2023-10-05 WO disclosed
WO-2023164680-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS RECLUDIX PHARMA, INC. (US) 2023-08-31 WO disclosed
US-8536336-B2 Prodrug compounds useful as cannabinoid ligands ABBVIE INC. (US) 2013-09-17 US disclosed
WO-2011075522-A1 PRODRUG COMPOUNDS USEFUL AS CANNABINOID LIGANDS ABBOTT LABORATORIES (US) 2011-06-23 WO disclosed
US-20110144165-A1 PRODRUG COMPOUNDS USEFUL AS CANNABINOID LIGANDS ABBOTT LABORATORIES (US) 2011-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179103-A1 6-OXODECAHYDROPYRROLO[1,2-A][1,5]DIAZOCINE AND 6-OXODECAHYDRO-4H-PYRROLO[2,1-D][1,5]THIAZOCINE DERIVATIVES AS STAT3 AND STAT6 MODULATORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY CONDITIONS STAT6, STAT3, STAT1 POLB 4310/4885RAB9A 3546/4885FKBP1A 1523/4885
US-20110144165-A1 PRODRUG COMPOUNDS USEFUL AS CANNABINOID LIGANDS CNR2, CNR1, OPRL1 POLB 3056/4885RAB9A 704/4885FKBP1A 768/4885
US-20250215030-A1 STAT MODULATORS AND USES THEREOF STAT6, STAT3, STAT5A POLB 4657/4885RAB9A 2889/4885FKBP1A 1213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.