Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.51 |
| ▸ | PEPD | P12955 | 2/20 | 0.48 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30599979 | 1.00 | POLB (0.58) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL70309 | 0.94 | FKBP1A (0.57) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL3009795 | 0.86 | FKBP1A (0.54) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL3009794 | 0.86 | FKBP1A (0.54) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL5499151 | 0.86 | FKBP1A (0.54) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL468720 | 0.85 | POLB (0.58) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL9533366 | 0.85 | POLB (0.62) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL13864545 | 0.85 | RAB9A (0.45) | POLBFKBP1ARAB9ATSHRALDH1A1 | |
| SCHEMBL14426613 | 0.85 | POLB (0.58) | POLBFKBP1APEPDXPNPEP1RAB9A | |
| SCHEMBL2037827 | 0.85 | POLB (0.58) | POLBFKBP1APEPDXPNPEP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993023404-A1 | COMPOUNDS THAT MODULATE ENDOTHELIN ACTIVITY | IMMUNOPHARMACEUTICS, INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0307140-A1 | Oxadiazolyl-azabicycloheptanes for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |