Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YEATS4 | O95619 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21230299 | 0.93 | YEATS4 (0.45) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL3241197 | 0.92 | HPGD (0.44) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775106 | 0.91 | HPGD (0.45) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775117 | 0.90 | NPC1 (0.49) | YEATS4HPGDALDH1A1HDAC4HDAC1 | |
| SCHEMBL19775370 | 0.90 | HPGD (0.50) | YEATS4HPGDALDH1A1HDAC4NPC1 | |
| SCHEMBL20082245 | 0.89 | P2RY14 (0.39) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775352 | 0.89 | GABRA5 (0.39) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775154 | 0.89 | SPR (0.40) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775404 | 0.88 | YEATS4 (0.37) | YEATS4HPGDALDH1A1MAPK14HDAC4 | |
| SCHEMBL19775125 | 0.88 | SPR (0.39) | YEATS4HPGDALDH1A1MAPK14HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311813-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2019-08-07 | — | — | EP | disclosed |
| EP-3311813-A1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | Dart Neuroscience (Cayman) Ltd (KY) | 2018-04-25 | — | — | EP | disclosed |
| EP-2182809-B1 | THERAPEUTIC ISOXAZOLE COMPOUNDS | DART NEUROSCIENCE (CAYMAN) LTD (KY) | 2018-01-17 | — | — | EP | disclosed |