SCHEMBL1978120

SCHEMBL1978120

CCOC(=O)C(=O)c1ccc2c(c1)c1ccccc1n2C(C)CC

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.45
ALDH1A1 P00352 2/20 0.45
HPGD P15428 2/20 0.45
PTGER4 P35408 1/20 0.44
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CNR2 P34972 3/20 0.43
RORC P51449 1/20 0.43
SCARB1 Q8WTV0 1/20 0.41
DHODH Q02127 1/20 0.41
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12596935 0.94 HCAR3 (0.40) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL13640244 0.89 HCAR3 (0.38) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL18807617 0.89 HCAR3 (0.38) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL27867364 0.85 KDM4E (0.52) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL21636235 0.83 KDM4E (0.61) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL6312041 0.81 RECQL (0.49) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL4728742 0.78 PTGER4 (0.62) KDM4EALDH1A1HPGDPTGER4MAPT
SCHEMBL1979651 0.77 ALDH1A1 (0.47) KDM4EALDH1A1HPGDMAPTMAPK1
SCHEMBL18807711 0.76 CNR2 (0.41) KDM4EALDH1A1HPGDMAPTMAPK1
SCHEMBL4727898 0.76 PTGER4 (0.53) KDM4EALDH1A1HPGDPTGER4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509948-B1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA GRAPHICS NV (BE) 2017-05-03 EP disclosed
EP-2509948-B1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA GRAPHICS NV (BE) 2017-05-03 EP disclosed
EP-2510400-B1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA GRAPHICS NV (BE) 2015-04-29 EP disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8569393-B2 UV-LED curable compositions and inks AGFA-GEVAERT N.V. (BE) 2013-10-29 US disclosed
US-8569393-B2 UV-LED curable compositions and inks AGFA-GEVAERT N.V. (BE) 2013-10-29 US disclosed
US-8569393-B2 UV-LED curable compositions and inks AGFA-GEVAERT N.V. (BE) 2013-10-29 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120283349-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-11-08 US disclosed
US-20120283349-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-11-08 US disclosed
US-20120283349-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-11-08 US disclosed
EP-2510400-A1 UV-LED CURABLE COMPOSITIONS AND INKS Agfa-Gevaert (BE) 2012-10-17 EP disclosed
EP-2509948-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS Agfa-Gevaert (BE) 2012-10-17 EP disclosed
WO-2011069947-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT (BE) 2011-06-16 WO disclosed
WO-2011069943-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT (BE) 2011-06-16 WO disclosed
WO-2011069943-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT (BE) 2011-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS WEE1, CBX4, USP9X KDM4E 1156/4885ALDH1A1 1029/4885HPGD 3146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.