CBX4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL30315936	1.00	3/20
SCHEMBL29613505	0.91	3/20
SCHEMBL27223064	0.89	3/20
SCHEMBL27232005	0.89	3/20
SCHEMBL23682719	0.87	3/20
SCHEMBL23682865	0.87	3/20
SCHEMBL23717921	0.87	3/20
SCHEMBL23718040	0.87	3/20
SCHEMBL26219950	0.87	3/20
SCHEMBL29613457	0.79	3/20
SCHEMBL23815561	0.78	3/20
SCHEMBL24510752	0.78	3/20
SCHEMBL23718039	0.75	3/20
SCHEMBL23815796	0.75	3/20
SCHEMBL24510878	0.74	3/20
SCHEMBL24510644	0.72	3/20
SCHEMBL23682687	0.72	3/20
SCHEMBL23815823	0.72	3/20
SCHEMBL25049665	0.72	3/20
SCHEMBL23682653	0.72	3/20

Clinical trials — most relevant to CBX4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Olaparib in Patients With HRD Malignant Mesothelioma	PHASE2	RECRUITING
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer	PHASE1/PHASE2	SUSPENDED
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
Characterization of At-risk Population for Pre-sacral Tumor in CURRARINO Syndrome	nan	COMPLETED
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Identification of New Prognostic Markers for Breast Cancer.	nan	RECRUITING
Tissue Bank of Biological Specimens From Patients With Gynecologic Disease	nan	UNKNOWN
Immunophenotyping and Xist Gene in AML	nan	UNKNOWN
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.	nan	UNKNOWN
The Clinical Study of Sex Chromosome Variants	nan	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
Chordoma Family Study	nan	COMPLETED
Cause of Familial Testicular Cancer	nan	COMPLETED
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Next-Generation Sequencing-based Germline and Somatic Genetic Testing in Triple-negative Breast Cancer	nan	UNKNOWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing	nan	RECRUITING
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CBX4 binder may also engage these)

Protein	Name	Similarity
O55187	—	1.000	O55187 →
CBX6	Chromobox protein homolog 6	0.998	landscape →
Q5TGY3	—	0.995	Q5TGY3 →
Q9P1Z0	—	0.995	Q9P1Z0 →
P48435	—	0.994	P48435 →
Q8BSD5	—	0.994	Q8BSD5 →
P30658	—	0.994	P30658 →
Q04888	—	0.994	Q04888 →
O54963	—	0.994	O54963 →
Q5VZ18	—	0.993	Q5VZ18 →
O95886	—	0.993	O95886 →
Q8BZ32	—	0.993	Q8BZ32 →
Q00417	—	0.993	Q00417 →
A5PK23	—	0.993	A5PK23 →
O55170	—	0.992	O55170 →
Q96RK0	—	0.992	Q96RK0 →
CBX2	Chromobox protein homolog 2	0.992	landscape →
Q9CWL2	—	0.992	Q9CWL2 →
MIDEAS	Mitotic deacetylase-associated SANT domain protein	0.992	landscape →
P97838	—	0.992	P97838 →
Q9JL04	—	0.992	Q9JL04 →
P70459	—	0.992	P70459 →
TCF7	Transcription factor 7 (TCF-7) (T-cell-specif	0.992	landscape →
Q5S6V2	—	0.992	Q5S6V2 →
Q9DBY5	—	0.992	Q9DBY5 →
P24899	—	0.992	P24899 →
Q6PFD5	—	0.992	Q6PFD5 →
Q8WUU4	—	0.992	Q8WUU4 →
Q7TN02	—	0.992	Q7TN02 →
KDM3B	Lysine-specific demethylase 3B	0.991	landscape →