Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19782390 | 0.90 | DHODH (0.36) | DHODHNOX1CYP3A4MAPTKDM4E | |
| SCHEMBL19783106 | 0.86 | DHODH (0.53) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL19782395 | 0.85 | CDC7 (0.40) | DHODHMAPTKDM4E | |
| SCHEMBL19782392 | 0.84 | DHODH (0.40) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL19782989 | 0.84 | DHODH (0.43) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL19783003 | 0.78 | ADORA3 (0.41) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL19782384 | 0.74 | ALDH1A1 (0.38) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL15993345 | 0.74 | DHODH (0.58) | DHODHMAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL19782389 | 0.73 | DHODH (0.38) | DHODHMAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL15993076 | 0.73 | NPC1 (0.48) | DHODHMAPTKDM4EKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |