Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAMTS13 | Q76LX8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 8/20 | 0.34 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19783018 | 0.83 | ADAMTS5 (0.50) | ADAMTS5ADAMTS4MMP14ADAMTS13ADORA2A | |
| SCHEMBL19783019 | 0.78 | ALDH1A1 (0.42) | ADAMTS5ADAMTS4MMP14ADAMTS13NPC1 | |
| SCHEMBL19782715 | 0.77 | ADORA2A (0.40) | ADORA2AADORA1NPC1RAB9AMAPT | |
| SCHEMBL19783107 | 0.75 | ALDH1A1 (0.47) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19782726 | 0.70 | LMNA (0.56) | ADORA2AADORA1NPC1RAB9AMAPT | |
| SCHEMBL23965805 | 0.67 | NPC1 (0.60) | ADORA1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL19782991 | 0.66 | MAPT (0.60) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27973907 | 0.66 | KDR (0.36) | ADAMTS5ADAMTS4MMP14ADAMTS13ADORA2A | |
| SCHEMBL19782984 | 0.66 | ADAMTS5 (0.52) | ADAMTS5ADAMTS4MMP14ADAMTS13ADORA2A | |
| SCHEMBL1017978 | 0.65 | KMT2A (0.51) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |