Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RELA | Q04206 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | MECP2 | P51608 | 1/20 | 0.60 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.60 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.60 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.60 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.60 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017669 | 0.87 | ALDH1A1 (0.67) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL23222310 | 0.81 | ALDH1A1 (0.65) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL24257646 | 0.81 | NPY5R (0.64) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL7678939 | 0.80 | MAPT (0.81) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL24257641 | 0.79 | MAPT (0.62) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL24257655 | 0.79 | MAPT (0.57) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL24257425 | 0.79 | MAPT (0.62) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| Bromide SCHEMBL7673197 | 0.79 | MAPT (0.79) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| SCHEMBL3915911 | 0.78 | MAPT (0.88) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A | |
| Bromide SCHEMBL6930883 | 0.77 | MAPT (0.86) | MAPTSMN1; SMN2NFKB1NFKB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913734-B2 | Substituted aminothiazoles | BARUCH S. BLUMBERG INSTITUTE | 2021-02-09 | — | — | US | disclosed |
| US-20190241552-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE | 2019-08-08 | — | — | US | disclosed |
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913734-B2 | Substituted aminothiazoles | ABAT, AADAT, BCAT1 | MAPT 307/4885SMN1; SMN2 1331/4885NFKB1 4036/4885 |
| US-20190241552-A1 | SUBSTITUTED AMINOTHIAZOLES | ABAT, AADAT, BCAT1 | MAPT 307/4885SMN1; SMN2 1331/4885NFKB1 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.