Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615985 | 0.82 | NOTUM (0.78) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL16122204 | 0.79 | NOTUM (0.53) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL17470882 | 0.79 | NOTUM (0.53) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL1741532 | 0.76 | NOTUM (0.50) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL6360574 | 0.73 | CHRNB2 (0.48) | NOTUMF2ALDH1A1HPGDTDP1 | |
| SCHEMBL4778151 | 0.73 | NOTUM (0.50) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL311636 | 0.72 | MAPT (1.00) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL1163779 | 0.72 | NOTUM (0.64) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL11831417 | 0.72 | NOTUM (0.64) | NOTUMMAPTF2KCNJ1ALDH1A1 | |
| SCHEMBL82595 | 0.72 | MAPT (0.69) | NOTUMMAPTF2KCNJ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016263-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016263-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, SLC9A1 | NOTUM 4300/4885MAPT 4238/4885F2 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.