Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20909038 | 0.84 | CYP11B2 (0.45) | PTPN11CYP11B2CYP11B1TTKDYRK1A | |
| SCHEMBL19785348 | 0.80 | PTPN11 (0.64) | PTPN11EGFRKCNH2 | |
| SCHEMBL25713879 | 0.76 | PTPN11 (0.71) | PTPN11EGFRKCNH2 | |
| SCHEMBL23510860 | 0.74 | PTPN11 (0.40) | PTPN11EGFRKCNH2CYP11B2CYP11B1 | |
| SCHEMBL24541893 | 0.74 | PTPN11 (0.37) | PTPN11EGFRKCNH2CYP11B2CYP11B1 | |
| SCHEMBL19785390 | 0.71 | PTPN11 (0.46) | PTPN11EGFRKCNH2CYP11B2CYP11B1 | |
| SCHEMBL19785579 | 0.70 | PTPN11 (0.49) | PTPN11EGFRKCNH2 | |
| SCHEMBL20909052 | 0.69 | PTPN11 (0.42) | PTPN11KCNH2CYP11B2 | |
| SCHEMBL25124236 | 0.68 | PTPN11 (0.41) | PTPN11EGFRKCNH2CYP11B2CYP11B1 | |
| SCHEMBL23186804 | 0.68 | KIF18A (0.46) | PTPN11EGFRKCNH2CYP11B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484856-B1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-11-15 | — | — | EP | disclosed |
| WO-2018013597-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | Revolution Medicines, Inc. (US) | 2018-01-18 | — | — | WO | disclosed |