Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 3/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598125 | 0.94 | DRD2 (0.48) | WNT1DYRK1ATLR9TLR7TLR8 | |
| SCHEMBL12598121 | 0.89 | KDM4E (0.44) | WNT1DYRK1ATLR9TLR7TLR8 | |
| SCHEMBL1983761 | 0.88 | BRAF (0.47) | WNT1DYRK1ATLR9TLR7 | |
| SCHEMBL1980365 | 0.87 | TLR7 (0.52) | WNT1DYRK1ATLR9TLR7TLR8 | |
| SCHEMBL1981803 | 0.87 | MTNR1A (0.45) | TLR9TLR7TLR8 | |
| SCHEMBL1979799 | 0.87 | TP53 (0.41) | DYRK1ATLR7CHEK1ACHE | |
| SCHEMBL1979171 | 0.86 | WNT1 (0.42) | WNT1DYRK1ATLR9TLR7TLR8 | |
| SCHEMBL1981315 | 0.86 | PTAFR (0.47) | WNT1DYRK1ATLR9TLR7 | |
| SCHEMBL1981901 | 0.86 | CHEK1 (0.40) | WNT1DYRK1ATLR9TLR7TLR8 | |
| SCHEMBL12598112 | 0.86 | TLR7 (0.45) | DYRK1ATLR9TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |