Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 12/20 | 0.43 |
| ▸ | DHODH | Q02127 | 11/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785975 | 0.85 | L3MBTL1 (0.58) | L3MBTL1MTNR1BRORCDHODHHSD11B1 | |
| SCHEMBL19785608 | 0.85 | RORC (0.51) | RORC | |
| SCHEMBL18658594 | 0.81 | RORC (0.55) | L3MBTL1MTNR1BRORCDHODHHSD11B1 | |
| SCHEMBL19785787 | 0.79 | MGLL (0.41) | ALDH1A1KDM4E | |
| SCHEMBL19785610 | 0.78 | VEGFA (0.42) | L3MBTL1ALDH1A1KDM4EMAPT | |
| SCHEMBL30642978 | 0.76 | RORC (0.49) | L3MBTL1MTNR1BRORCDHODHALDH1A1 | |
| SCHEMBL19785934 | 0.76 | RORC (0.47) | L3MBTL1RORCDHODH | |
| SCHEMBL21354323 | 0.74 | RORC (0.41) | RORC | |
| SCHEMBL19785899 | 0.74 | LMNA (0.42) | MEN1KMT2A | |
| SCHEMBL18658614 | 0.73 | RORC (0.62) | L3MBTL1MTNR1BRORCDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484880-B1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA AS (DK) | 2020-09-02 | — | — | EP | disclosed |
| WO-2018011201-A1 | HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2018-01-18 | — | — | WO | disclosed |