Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785828 | 0.86 | KDR (0.52) | KDRIRAK4PDCD1CD274ITK | |
| SCHEMBL19779868 | 0.82 | RORC (0.39) | IRAK4PDCD1CD274RORC | |
| SCHEMBL19785950 | 0.81 | TAS1R3 (0.45) | KDRTAS1R3TAS1R1TAS1R2RXFP1 | |
| SCHEMBL19785493 | 0.80 | PDCD1 (0.52) | KDRIRAK4PDCD1CD274ITK | |
| SCHEMBL19779671 | 0.75 | RORC (0.39) | IRAK4PDCD1CD274TAS1R3TAS1R1 | |
| SCHEMBL19785829 | 0.72 | TAS1R3 (0.46) | KDRTAS1R3TAS1R1TAS1R2RXFP1 | |
| SCHEMBL19779688 | 0.71 | RORC (0.40) | IRAK4PDCD1CD274RORC | |
| SCHEMBL19785758 | 0.68 | KDR (0.43) | KDRPDCD1CD274BTK | |
| SCHEMBL18979704 | 0.67 | PDCD1 (0.45) | IRAK4PDCD1CD274 | |
| SCHEMBL19779869 | 0.66 | PDCD1 (0.51) | IRAK4PDCD1CD274RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013789-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |