Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.65 |
| ▸ | DRD1 | P21728 | 3/20 | 0.65 |
| ▸ | HRH1 | P35367 | 3/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | FYN | P06241 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785933 | 0.94 | DRD2 (0.70) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorproethazine SCHEMBL149201 | 0.82 | CYP1A2 (0.77) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorproethazine SCHEMBL29818123 | 0.82 | CYP1A2 (0.77) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorproethazine SCHEMBL9724486 | 0.81 | LMNA (0.78) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| SCHEMBL19196333 | 0.80 | SIGMAR1 (0.74) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| SCHEMBL5880420 | 0.80 | ITGB2 (0.73) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorproethazine SCHEMBL1648952 | 0.80 | CYP1A2 (0.74) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorpromazine SCHEMBL8321 | 0.80 | CYP1A2 (1.00) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorpromazine SCHEMBL29358018 | 0.80 | CYP1A2 (1.00) | DRD2LMNACYP1A2HTR1ACYP2D6 | |
| Chlorpromazine SCHEMBL29367385 | 0.80 | CYP1A2 (1.00) | DRD2LMNACYP1A2HTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013761-A1 | CALMODULIN INHIBITORS, CHK2 INHIBITORS AND RSK INHIBITORS FOR THE TREATMENT OF RIBOSOMAL DISORDERS AND RIBOSOMAPATHIES | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-01-18 | — | — | WO | disclosed |