Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | POLA1 | P09884 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19786284 | 0.83 | POLA1 (0.53) | POLA1CYP3A4TSHRCYP2C9CYP2C19 | |
| SCHEMBL19770998 | 0.78 | CYP3A4 (0.47) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL19786218 | 0.71 | POLA1 (0.36) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL19786280 | 0.67 | CYP3A4 (0.61) | POLA1CYP3A4TSHRCYP2C9CYP2C19 | |
| SCHEMBL19770995 | 0.65 | CYP3A4 (0.72) | POLA1CYP3A4TSHRCYP2C9CYP2C19 | |
| SCHEMBL12827353 | 0.64 | OPRD1 (0.46) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL16499555 | 0.64 | OPRD1 (0.46) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL12825563 | 0.64 | OPRD1 (0.46) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL16499412 | 0.64 | OPRD1 (0.46) | OPRD1POLA1CYP3A4TSHRCYP2C9 | |
| SCHEMBL388758 | 0.64 | PGR (0.53) | ALDH1A1KDM4ELMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015051-A1 | MODULATORS OF ALPHA-DICARBONYL DETOXIFICATION AND THEIR USE FOR THE TREATMENT OF DIABETIC PATHOLOGIES | BUCK INST RES AGING (US) | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015051-A1 | MODULATORS OF ALPHA-DICARBONYL DETOXIFICATION AND THEIR USE FOR THE TREATMENT OF DIABETIC PATHOLOGIES | TRPA1, TRPV1, TRPM2 | OPRD1 410/4885POLA1 3859/4885CYP3A4 1475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.