⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25793920 | 0.78 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL12384804 | 0.76 | MEN1 (0.34) | — | |
| SCHEMBL18133869 | 0.72 | MEN1 (0.39) | — | |
| SCHEMBL23315939 | 0.69 | PHGDH (0.45) | — | |
| SCHEMBL23788363 | 0.69 | USP1 (0.32) | — | |
| SCHEMBL24852718 | 0.69 | OPRM1 (0.41) | — | |
| SCHEMBL22930177 | 0.69 | OPRM1 (0.34) | — | |
| SCHEMBL13154267 | 0.68 | SIGMAR1 (0.40) | — | |
| SCHEMBL25672740 | 0.67 | MEN1 (0.36) | — | |
| SCHEMBL25672658 | 0.67 | HRH3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646488-B2 | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof | ARAXES PHARMA LLC (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180015087-A1 | CONJUGATES OF CEREBLON BINDING COMPOUNDS AND G12C MUTANT KRAS, HRAS OR NRAS PROTEIN MODULATING COMPOUNDS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2018-01-18 | — | — | US | disclosed |