Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787673 | 0.77 | APP (0.46) | CSNK2A1APP | |
| SCHEMBL19787592 | 0.73 | ALOX15 (0.40) | EGFRCSNK2A1BCDIN3DKMT2AAURKA | |
| SCHEMBL19787605 | 0.72 | TXN (0.50) | EGFRKMT2AAURKAAPP | |
| SCHEMBL19787669 | 0.72 | TRPA1 (0.45) | EGFRGRM4APP | |
| SCHEMBL795933 | 0.69 | TSHR (0.46) | KMT2ATSHRAPP | |
| SCHEMBL22543336 | 0.69 | EGFR (0.48) | EGFRCSNK2A1GRM4KMT2A | |
| SCHEMBL30125903 | 0.64 | EGFR (0.55) | EGFR | |
| SCHEMBL30748761 | 0.64 | KDR (0.45) | EGFRKMT2A | |
| SCHEMBL31471933 | 0.64 | LMNA (0.60) | KMT2AAPP | |
| SCHEMBL2825501 | 0.64 | LMNA (0.60) | KMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415369-B | Fused pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-109311877-B | Fused pyrimidine derivatives | 豪夫迈·罗氏有限公司 | 2021-05-28 | — | — | CN | disclosed |
| EP-3481829-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-04-07 | — | — | EP | disclosed |
| EP-3484884-B1 | FUSED PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2018011164-A1 | FUSED PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-18 | — | — | WO | disclosed |