Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HLA-DRB1 | P01911 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193208 | 0.84 | NPSR1 (0.47) | HTTTYRNPSR1ALDH1A1LMNA | |
| SCHEMBL6858 | 0.84 | NPSR1 (0.47) | HTTTYRNPSR1ALDH1A1LMNA | |
| SCHEMBL1952824 | 0.84 | NPSR1 (0.47) | HTTTYRNPSR1ALDH1A1LMNA | |
| SCHEMBL10513380 | 0.84 | TYR (0.44) | MMEACECPA1ACE2HTT | |
| SCHEMBL753926 | 0.84 | TYR (0.44) | MMEACECPA1ACE2HTT | |
| SCHEMBL3551870 | 0.84 | TYR (0.44) | MMEACECPA1ACE2HTT | |
| SCHEMBL14862094 | 0.83 | BACE1 (0.40) | MMEACECPA1ACE2CTSS | |
| SCHEMBL12285510 | 0.83 | BACE1 (0.40) | MMEACECPA1ACE2CTSS | |
| SCHEMBL12245283 | 0.83 | BACE1 (0.40) | MMEACECPA1ACE2CTSS | |
| SCHEMBL29613052 | 0.82 | MME (0.41) | MMEACECPA1ACE2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799595-B2 | Pyrrolobenzodiazepine conjugates | MEDIMMUNE LIMITED (GB) | 2020-10-13 | — | — | US | disclosed |
| US-20190282705-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2019-09-19 | — | — | US | disclosed |
| US-20190144443-A1 | ASYMMETRIC CONJUGATE COMPOUNDS | PHEON THERAPEUTICS LTD (GB) | 2019-05-16 | — | — | US | disclosed |
| US-9873716-B2 | Macrocyclic inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2018-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190282705-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | GABRE, GRIN2B, GABRB1 | MME 3456/4885ACE 3435/4885CPA1 3520/4885 |
| US-10799595-B2 | Pyrrolobenzodiazepine conjugates | GABRE, GRIN2B, GABRB1 | MME 3456/4885ACE 3435/4885CPA1 3520/4885 |
| US-20190144443-A1 | ASYMMETRIC CONJUGATE COMPOUNDS | TUBA1C, MTX2, CCNO | MME 1727/4885ACE 3636/4885CPA1 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.