Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828560 | 0.76 | — | — | |
| SCHEMBL11890489 | 0.72 | — | — | |
| SCHEMBL19821916 | 0.71 | MTNR1A (0.37) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL30208805 | 0.69 | CRBN (0.36) | KDM4EMAPK1HIF1AMTNR1AMTNR1B | |
| SCHEMBL6962867 | 0.68 | — | — | |
| SCHEMBL18598077 | 0.68 | BCHE (0.34) | KDM4ETSHR | |
| SCHEMBL10781738 | 0.67 | — | — | |
| SCHEMBL11365507 | 0.67 | MGAM (0.38) | TSHR | |
| SCHEMBL12423988 | 0.67 | TSHR (0.47) | KDM4EMAPK1HIF1ATSHR | |
| SCHEMBL30960337 | 0.67 | TSHR (0.44) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |