Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823332 | 0.81 | KMT2A (0.55) | MAPT | |
| SCHEMBL449103 | 0.77 | AKR1B1 (0.50) | BACE1AKR1B1 | |
| SCHEMBL445231 | 0.77 | BACE1 (0.49) | BACE1AKR1B1 | |
| SCHEMBL29134774 | 0.77 | BACE1 (0.44) | BACE1AKR1B1MAPT | |
| SCHEMBL1982939 | 0.77 | AKR1B10 (0.71) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL12592081 | 0.76 | BACE1 (0.61) | BACE1 | |
| SCHEMBL24699359 | 0.76 | BACE1 (0.48) | BACE1AKR1B1MAPT | |
| SCHEMBL30016504 | 0.76 | BACE1 (0.48) | BACE1AKR1B1MAPT | |
| SCHEMBL10787723 | 0.73 | ALDH1A1 (0.41) | MAPT | |
| SCHEMBL1981628 | 0.73 | BACE1 (0.68) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |