Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20078937 | 0.82 | LMNA (0.33) | ADORA3ADORA2AADORA1ELANEKDM4E | |
| SCHEMBL24878752 | 0.78 | ALDH1A1 (0.35) | HPGDELANEKDM4ELMNAALDH1A1 | |
| SCHEMBL19788768 | 0.78 | KMT2A (0.32) | ADORA3ADORA2AADORA1ELANEKDM4E | |
| SCHEMBL17616500 | 0.78 | KMT2A (0.32) | ADORA3ADORA2AADORA1ELANEKDM4E | |
| SCHEMBL17697354 | 0.66 | PDE4A (0.36) | ELANEKDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL21420081 | 0.66 | MAPK1 (0.35) | HPGDKDM4EALDH1A1KMT2AHSD17B10 | |
| SCHEMBL21420082 | 0.66 | MAPK1 (0.35) | HPGDKDM4EALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4038348 | 0.66 | ADORA3 (0.46) | ADORA3ADORA2AADORA1HPGDELANE | |
| SCHEMBL24998978 | 0.64 | SMN1; SMN2 (0.30) | — | |
| SCHEMBL22001985 | 0.64 | MAPK1 (0.35) | KDM4EALDH1A1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873680-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-01-23 | — | — | US | disclosed |