Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982548 | 0.90 | ERN1 (0.46) | TLR7TLR9TLR8ABL1BCR | |
| SCHEMBL1980375 | 0.88 | JAK2 (0.45) | TLR7TLR9TLR8ABL1BCR | |
| SCHEMBL1983761 | 0.88 | BRAF (0.47) | TLR7TLR9DYRK1AWNT1BRAF | |
| SCHEMBL1981315 | 0.84 | PTAFR (0.47) | TLR7TLR9DYRK1AWNT1BRAF | |
| SCHEMBL12597441 | 0.82 | TLR8 (0.49) | TLR7TLR9TLR8ABL1BCR | |
| SCHEMBL1981803 | 0.81 | MTNR1A (0.45) | TLR7TLR9TLR8KMT2ABRAF | |
| SCHEMBL1979088 | 0.81 | WNT1 (0.51) | TLR7TLR9TLR8ABL1BCR | |
| SCHEMBL12598112 | 0.80 | TLR7 (0.45) | TLR7TLR9TLR8KMT2ADYRK1A | |
| SCHEMBL1981277 | 0.80 | WNT1 (0.49) | TLR7TLR9TLR8ABL1BCR | |
| SCHEMBL12598125 | 0.80 | DRD2 (0.48) | TLR7TLR9TLR8DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |