Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Podofilox. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.77 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.77 |
| ▸ | TUBB | P07437 | 4/20 | 0.77 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.77 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.77 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.77 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.77 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.77 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.77 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.77 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.77 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.77 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.77 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.77 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.77 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Podofilox SCHEMBL9000061 | 0.88 | LMNA (0.85) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL10046308 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Epipodophyllotoxin SCHEMBL5792464 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL30947382 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL12377923 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL24049951 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL13661743 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL13663652 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL20807187 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL42243 | 0.88 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101647842-B | Fructus Podophylli extract and application thereof | UNIV BEIJING | 2011-08-31 | — | — | CN | claimed |
| CN-101647842-A | Fructus Podophylli extract and application thereof | UNIV BEIJING | 2010-02-17 | — | — | CN | claimed |
| CN-112912143-A | Small molecule MDM2 protein degradation agent | 美国密歇根州立大学试剂中心 | 2021-06-04 | — | — | CN | disclosed |
| EP-2346876-B1 | NOVEL 4BETA-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-30 | — | — | EP | disclosed |
| US-8354547-B2 | 4β-amino podophyllotoxin congeners as anti tumour antibiotics a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-01-15 | — | — | US | disclosed |
| US-20110213165-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-01 | — | — | US | disclosed |
| CN-101647842-B | Fructus Podophylli extract and application thereof | UNIV BEIJING | 2011-08-31 | — | — | CN | disclosed |
| EP-2346876-A1 | NOVEL 4BETA-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| US-7960418-B2 | Cytotoxic 4 beta -[4''-(1'',3''-benzothiazole-2''-yl)anilino]-4-desoxypodophyllotoxin anticarcinogenic agent; prepared by amination with a 4-(1,3-benzothiazole-2-yl)aniline compound; new chemical derivatives from PODOPHYLLOTOXIN, as antitumor antibiotics | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-06-14 | — | — | US | disclosed |
| CN-101974006-A | Method for extracting podophyllotoxin from umbrella leaf | NANJING ZELANG MEDICAL TECH CO | 2011-02-16 | — | — | CN | disclosed |
| WO-2010052733-A1 | NOVEL 4β-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | disclosed |
| WO-2003082876-A1 | 4-BETA-1''-`(2''-(SUBSTITUTED BENZOYL)ANILINO! PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-10-09 | — | — | WO | disclosed |
| WO-2003048166-A1 | PODOPHYLLOTOXINS AS ANTIPROLIFERATIVE AGENTS | UNIVERSITÄTSKLINIKUM CHARITE DER HUMBOLDT-UNIVERSITÄT ZU BERLIN TECHNOLOGIE TRANSFERSTELLE (DE) | 2003-06-12 | — | — | WO | disclosed |
| US-20020082432-A1 | New podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH | 2002-06-27 | — | — | US | disclosed |
| EP-1071754-A4 | RECOMBINANT SECOISOLARICIRESINOL DEHYDROGENASE, AND METHODS OF USE | UNIV WASHINGTON (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2001012209-A1 | ENHANCED YIELD OF PODOPHYLLOTOXIN FROM NATURAL PRODUCTS THROUGH IN SITU CONVERSION METHODS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2001-02-22 | — | — | WO | disclosed |
| EP-1071754-A1 | RECOMBINANT SECOISOLARICIRESINOL DEHYDROGENASE, AND METHODS OF USE | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2001-01-31 | — | — | EP | disclosed |
| US-6143304-A | HYDROLYSIS OF CORRESPONDING GLUCOSIDE | THE UNIVERSITY OF MISSISSIPPI (US) | 2000-11-07 | — | — | US | disclosed |
| WO-1999055846-A1 | RECOMBINANT SECOISOLARICIRESINOL DEHYDROGENASE, AND METHODS OF USE | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1999-11-04 | — | — | WO | disclosed |
| US-4486445-A | OBTAINED FROM JUSTICIA EXTENSA | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213165-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | EIF4B, TUBB4B, TUBB4A | LMNA 1287/4885CYP3A4 591/4885TUBB4A 3/4885 |
| US-20020082432-A1 | New podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore | TOP2A, TOP2B, PCNA | LMNA 99/4885CYP3A4 2013/4885TUBB4A 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.