Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504640 | 0.83 | TTR (0.52) | TTRALBMEN1KMT2APGR | |
| SCHEMBL200313 | 0.78 | TTR (0.52) | TTRALBMEN1KMT2APGR | |
| SCHEMBL28671409 | 0.75 | CYP1A1 (0.43) | — | |
| SCHEMBL31040201 | 0.74 | GRM5 (0.33) | GRM5 | |
| SCHEMBL1981891 | 0.74 | GRM5 (0.33) | GRM5 | |
| SCHEMBL29954891 | 0.74 | ENPP2 (0.48) | TTRALBMEN1KMT2AGRM5 | |
| SCHEMBL16951758 | 0.73 | TTR (0.43) | TTRALBMEN1KMT2APGR | |
| SCHEMBL30345274 | 0.73 | TTR (0.43) | TTRALBMEN1KMT2APGR | |
| SCHEMBL254589 | 0.73 | TTR (0.43) | TTRALBMEN1KMT2APGR | |
| SCHEMBL3509168 | 0.73 | TTR (0.43) | TTRALBMEN1KMT2APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |