SCHEMBL504640

SCHEMBL504640

N#Cc1cc(Br)cc(C#N)c1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.52
ALB P02768 2/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
MAOB P27338 2/20 0.41
MAOA P21397 1/20 0.41
HTT P42858 1/20 0.38
VCAM1 P19320 2/20 0.37
TSHR P16473 1/20 0.36
PGR P06401 1/20 0.35
ALDH1A1 P00352 1/20 0.33
CYP2A6 P11509 1/20 0.33
CA12 O43570 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
GPR35 Q9HC97 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL200313 0.94 TTR (0.52) TTRALBMEN1KMT2AMAOB
SCHEMBL16951758 0.87 TTR (0.43) TTRALBMEN1KMT2AMAOB
SCHEMBL19062532 0.84 TTR (0.44) TTRALBMEN1KMT2AMAOB
SCHEMBL16950941 0.84 TTR (0.44) TTRALBMEN1KMT2AMAOB
SCHEMBL1979138 0.83 TTR (0.40) TTRALBMEN1KMT2AMAOB
SCHEMBL60145 0.83 TTR (0.50) TTRALBMEN1KMT2AVCAM1
SCHEMBL254589 0.82 TTR (0.43) TTRALBMEN1KMT2AMAOB
SCHEMBL12514204 0.82 TTR (0.43) TTRALBMEN1KMT2AMAOB
SCHEMBL1883717 0.82 TTR (0.54) TTRALBMEN1KMT2AMAOB
SCHEMBL505159 0.82 MEN1 (0.43) TTRALBMEN1KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115772139-A 2, 3-benzophenothiazine derivative, preparation method and application 南京邮电大学 2023-03-10 CN claimed
CN-113845491-A Benzophenothiazine derivatives and process for their preparation 南京邮电大学 2021-12-28 CN claimed
US-20260055083-A1 APOL1 INHIBITORS AND METHODS OF USE MAZE THERAPEUTICS INC (US) 2026-02-26 US disclosed
US-20260027113-A1 PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE SOLEY THERAPEUTICS INC (US) 2026-01-29 US disclosed
US-12465603-B2 Phthalazinone based modulators for the treatment of disease SOLEY THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
EP-4619387-A1 PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE Soley Therapeutics, Inc. (US) 2025-09-24 EP disclosed
WO-2025135309-A1 ORGANIC LIGHT-EMITTING COMPOUND, AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 솔루스첨단소재 주식회사 2025-06-26 WO disclosed
EP-4573077-A1 APOL1 INHIBITORS AND METHODS OF USE Maze Therapeutics, Inc. (US) 2025-06-25 EP disclosed
CN-120157679-A Dendritic luminescent material based on space charge transfer, preparation method and application 长春理工大学 2025-06-17 CN disclosed
CN-111196780-B Organic electroluminescent device and compound for organic electroluminescent device 三星显示有限公司 2025-01-07 CN disclosed
WO-2024249252-A1 METHODS OF USING APOL1 INHIBITORS MAZE THERAPEUTICS, INC. (US) 2024-12-05 WO disclosed
CN-1349516-A Cyclothiocarbamate derivatives as progesterone receptor modulators AMERICAN HOME PROD (US) 2002-05-15 CN disclosed
US-20020049204-A1 Cyclocarbamate derivatives as progesterone receptor modulators WYETH 2002-04-25 US disclosed
EP-1173210-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC American Home Products Corporation (US) 2002-01-23 EP disclosed
EP-1173426-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS American Home Products Corporation (US) 2002-01-23 EP disclosed
CN-1284074-A Novel compounds ASTRA ZENECA BRITISH LTD (GB) 2001-02-14 CN disclosed
WO-2000066571-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066164-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
EP-1037889-A1 NOVEL COMPOUNDS AstraZeneca UK Limited (GB) 2000-09-27 EP disclosed
WO-1999029686-A1 NOVEL COMPOUNDS ASTRAZENECA UK LIMITED (GB) 1999-06-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12465603-B2 Phthalazinone based modulators for the treatment of disease MKI67, BCL2, CCAR2 TTR 3982/4885ALB 4493/4885MEN1 1555/4885
US-20260027113-A1 PHTHALAZINONE BASED MODULATORS FOR THE TREATMENT OF DISEASE NCOR1, NOP56, NCOR2 TTR 3135/4885ALB 3875/4885MEN1 2848/4885
US-20260055083-A1 APOL1 INHIBITORS AND METHODS OF USE APOL1, LDLR, APOB TTR 122/4885ALB 1330/4885MEN1 2120/4885
US-20020049204-A1 Cyclocarbamate derivatives as progesterone receptor modulators NR3C1, NR5A1, CNR1 TTR 3970/4885ALB 4428/4885MEN1 3804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.