Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.64 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194137 | 0.82 | MET (0.64) | METRAPGEF4RPS6KA5 | |
| SCHEMBL31428856 | 0.82 | MET (0.64) | METRAPGEF4RPS6KA5 | |
| SCHEMBL29847431 | 0.78 | MET (1.00) | METRAPGEF4 | |
| SCHEMBL3705420 | 0.78 | MET (1.00) | METRAPGEF4 | |
| SCHEMBL31405708 | 0.74 | MET (0.62) | METRAPGEF4RPS6KA5 | |
| SCHEMBL30711140 | 0.74 | MET (0.76) | METRAPGEF4 | |
| SCHEMBL3616325 | 0.74 | MET (0.76) | METRAPGEF4 | |
| SCHEMBL830432 | 0.74 | ALDH3A1 (0.57) | — | |
| SCHEMBL15175252 | 0.72 | RAPGEF4 (1.00) | METRAPGEF4 | |
| SCHEMBL16824192 | 0.71 | MET (0.84) | METRAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015445-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-25 | — | — | WO | disclosed |
| EP-3272739-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-24 | — | — | EP | disclosed |
| EP-3272739-A1 | SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY | NodThera Limited (GB) | 2018-01-24 | — | — | EP | disclosed |