Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978302 | 0.85 | MAPK1 (0.43) | LDHAMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL1978847 | 0.81 | HPGD (0.45) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL17441559 | 0.77 | MEN1 (0.35) | LDHAMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL31433104 | 0.73 | MMP14 (0.36) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL19110513 | 0.68 | LDHA (0.44) | LDHAMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL2531951 | 0.67 | POLB (0.54) | MEN1KMT2AMAPTRXRARXRB | |
| SCHEMBL16468401 | 0.66 | MAP4K4 (0.42) | LDHAMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL31432963 | 0.65 | HRH2 (0.42) | MEN1KMT2ALMNAMAPK1MAPT | |
| SCHEMBL27601384 | 0.64 | KMT2A (0.49) | LDHAMEN1KMT2ALMNAMAPT | |
| SCHEMBL15897779 | 0.64 | RAB9A (0.43) | LDHAMEN1KMT2ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |