Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979237 | 0.85 | LDHA (0.36) | MAPK1LDHARXRARXRBMEN1 | |
| SCHEMBL1978847 | 0.82 | HPGD (0.45) | MAPK1MEN1KMT2ALMNAMAPT | |
| SCHEMBL17441559 | 0.78 | MEN1 (0.35) | MAPK1LDHARXRARXRBMEN1 | |
| SCHEMBL3609539 | 0.75 | ALDH1A1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL31433104 | 0.74 | MMP14 (0.36) | MAPK1MEN1KMT2ALMNAMAPT | |
| SCHEMBL19110513 | 0.73 | LDHA (0.44) | MAPK1LDHAFFAR1FFAR4SRD5A2 | |
| SCHEMBL16468401 | 0.70 | MAP4K4 (0.42) | MAPK1LDHAFFAR1FFAR4RXRA | |
| SCHEMBL4001 | 0.69 | HSD11B1 (0.57) | MAPK1MEN1KMT2ALMNARAB9A | |
| SCHEMBL20476548 | 0.67 | KMT2A (0.47) | MAPK1LDHAFFAR1FFAR4SRD5A2 | |
| SCHEMBL16468051 | 0.67 | LDHA (0.39) | MAPK1LDHAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |