SCHEMBL1983238

SCHEMBL1983238

COc1ccc(N)c(-c2cc(Cl)ncc2Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.47
HSP90AB1 P08238 2/20 0.47
KDM1A O60341 2/20 0.46
ALDH1A1 P00352 5/20 0.41
CYP3A4 P08684 3/20 0.41
CYP1A2 P05177 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
MAPT P10636 5/20 0.38
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
NOS2 P35228 3/20 0.38
THRB P10828 2/20 0.38
SCN10A Q9Y5Y9 1/20 0.38
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
NPC1 O15118 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1980018 0.85 KDM1A (0.34) HSP90AA1HSP90AB1KDM1ANOS2SCN10A
SCHEMBL1980019 0.85 CHEK2 (0.40) HSP90AA1HSP90AB1KDM1AALDH1A1
SCHEMBL1978207 0.78 ABL1 (0.36) KDM1A
SCHEMBL1978989 0.78 NPC1 (0.58) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL30206743 0.78 ALDH1A1 (0.61) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL30206740 0.78 ALDH1A1 (0.61) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL11004268 0.78 ALDH1A1 (0.61) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL1979322 0.76 MERTK (0.47) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL30206678 0.76 ALDH1A1 (0.65) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL31450003 0.72 HSP90AA1 (0.44) HSP90AA1HSP90AB1KDM1AALDH1A1SCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011070299-A1 TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-06-16 WO disclosed
WO-2011070298-A1 DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-06-16 WO disclosed
WO-2011070299-A1 TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-06-16 WO disclosed