Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 11/20 | 0.40 |
| ▸ | RXRA | P19793 | 10/20 | 0.40 |
| ▸ | RARG | P13631 | 6/20 | 0.40 |
| ▸ | RARA | P10276 | 9/20 | 0.35 |
| ▸ | RXRB | P28702 | 5/20 | 0.34 |
| ▸ | RXRG | P48443 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015371 | 1.00 | MAPK1 (0.41) | MAPK1ALDH1A1RARBRXRARARG | |
| SCHEMBL21662224 | 0.92 | HSD11B1 (0.38) | MAPK1ALDH1A1RARBRXRARARG | |
| SCHEMBL27328115 | 0.85 | RARB (0.47) | MAPK1ALDH1A1RARBRXRARARG | |
| SCHEMBL24807991 | 0.82 | RARB (0.58) | MAPK1ALDH1A1RARBRXRARARG | |
| SCHEMBL25129965 | 0.78 | RXRA (0.45) | RARBRXRARARGRARARXRB | |
| SCHEMBL29608697 | 0.78 | RXRA (0.45) | RARBRXRARARGRARARXRB | |
| SCHEMBL24809304 | 0.77 | RXRA (0.38) | MAPK1RARBRXRARARGRARA | |
| SCHEMBL18015524 | 0.77 | RXRA (0.32) | RXRA | |
| SCHEMBL21662016 | 0.76 | HSD11B1 (0.33) | RARBRXRARARG | |
| SCHEMBL24809301 | 0.75 | RXRA (0.40) | RARBRXRARARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| EP-3254317-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | MAPK1 4689/4885ALDH1A1 2742/4885RARB 2999/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | MAPK1 4164/4885ALDH1A1 2597/4885RARB 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.