Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 3/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21662224 | 0.84 | HSD11B1 (0.38) | HSD11B1RXRARARBRARGPGR | |
| SCHEMBL21662029 | 0.81 | RXRA (0.31) | RXRA | |
| SCHEMBL21662223 | 0.80 | HSD11B1 (0.47) | HSD11B1TNKS2 | |
| SCHEMBL24809304 | 0.79 | RXRA (0.38) | HSD11B1RXRARARBRARGPGR | |
| SCHEMBL18015371 | 0.76 | MAPK1 (0.41) | RXRARARBRARG | |
| SCHEMBL19794368 | 0.76 | MAPK1 (0.41) | RXRARARBRARG | |
| SCHEMBL27328115 | 0.71 | RARB (0.47) | RXRARARBRARG | |
| SCHEMBL24809860 | 0.70 | HSD11B1 (0.36) | HSD11B1PGR | |
| SCHEMBL21662169 | 0.70 | HSD11B1 (0.38) | HSD11B1PGR | |
| SCHEMBL21662017 | 0.69 | ALDH1A1 (0.42) | HSD11B1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601257-B1 | AROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2021-10-27 | — | — | EP | disclosed |
| US-20200039903-A1 | AROMATIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039903-A1 | AROMATIC COMPOUNDS | PAH, ALG3, DDC | HSD11B1 4586/4885RXRA 3429/4885RARB 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.