Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 6/20 | 0.36 |
| ▸ | FEN1 | P39748 | 8/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21125575 | 0.99 | HSD17B1 (0.42) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL23956040 | 0.96 | HSD17B1 (0.40) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL21125448 | 0.94 | KDM1A (0.40) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL19801345 | 0.91 | HSD17B1 (0.34) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL19794387 | 0.90 | HSD17B1 (0.41) | HSD17B1HSD17B2KDM1AMAOBCHRNB2 | |
| SCHEMBL20068776 | 0.88 | HSD17B1 (0.38) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL19933763 | 0.88 | HSD17B1 (0.38) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL18015488 | 0.87 | HSD17B1 (0.43) | HSD17B1HSD17B2KDM1AFEN1CHRNB2 | |
| SCHEMBL16905553 | 0.86 | HSD17B1 (0.45) | HSD17B1HSD17B2KDM1AFEN1MAOB | |
| SCHEMBL21125836 | 0.85 | DGAT1 (0.39) | HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | HSD17B1 4527/4885HSD17B2 4245/4885KDM1A 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.