Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207001 | 0.85 | ESR2 (0.46) | TSHRESR2ARKDM4EALDH1A1 | |
| SCHEMBL1472952 | 0.81 | TSHR (0.67) | TSHRESR2LRRK2ARKDM4E | |
| SCHEMBL1371322 | 0.81 | TSHR (0.39) | TSHRNISCHALDH1A1GAAHPGD | |
| SCHEMBL14480559 | 0.78 | — | — | |
| SCHEMBL222 | 0.76 | ESR2 (0.60) | TSHRESR2ARKDM4EALDH1A1 | |
| SCHEMBL29412287 | 0.76 | ESR2 (0.60) | TSHRESR2ARKDM4EALDH1A1 | |
| SCHEMBL229839 | 0.74 | — | — | |
| SCHEMBL2012045 | 0.74 | ACHE (0.41) | NISCHKDM4EALDH1A1GAAHPGD | |
| SCHEMBL29153430 | 0.74 | C1R (0.32) | NISCH | |
| SCHEMBL10506631 | 0.74 | PLA2G7 (0.44) | TSHRKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509978-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E.I. Du Pont De Nemours And Company (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072207-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |