SCHEMBL2012045

SCHEMBL2012045

Cc1c[c]ccc1-c1ccccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.41
MBNL1 Q9NR56 1/20 0.38
GAA P10253 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MGAM O43451 1/20 0.35
SI P14410 1/20 0.35
MGAM2 Q2M2H8 1/20 0.35
TNKS O95271 1/20 0.33
TNKS2 Q9H2K2 1/20 0.33
KCNN4 O15554 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
POLB P06746 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GPR3 P46089 1/20 0.33
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2053580 0.85 HSD11B1 (0.35) ACHEMBNL1GAANPC1RAB9A
SCHEMBL8129047 0.85 ACHE (0.41) ACHEMBNL1GAANPC1RAB9A
SCHEMBL1371322 0.84 TSHR (0.39) ACHEGAANPC1RAB9ASMN1; SMN2
SCHEMBL434024 0.84 KDM4E (0.34) ACHENPC1RAB9ASMN1; SMN2NISCH
SCHEMBL14480559 0.81
SCHEMBL2050739 0.81 ACHE (0.37) ACHECA9
SCHEMBL1205890 0.79 KDM4E (0.34) ACHENPC1RAB9ASMN1; SMN2NISCH
SCHEMBL2049865 0.78 NISCH (0.35) NISCHCA9
SCHEMBL2050053 0.78 DPP4 (0.35) NISCHKDM4EALDH1A1HPGDHSD17B10
SCHEMBL434626 0.77 KCNN4 (0.36) NPC1KCNN4NISCHKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed