Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | CLK3 | P49761 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25737820 | 0.80 | GSK3B (0.41) | DYRK1AGSK3BSMN1; SMN2 | |
| SCHEMBL16632983 | 0.75 | ALOX15 (0.38) | DYRK1AGSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL5623462 | 0.74 | L3MBTL1 (0.39) | TP53DYRK1AGSK3BKDM4EALDH1A1 | |
| SCHEMBL7996974 | 0.74 | KMT2A (0.38) | DYRK1AGSK3BKDM4EALDH1A1MEN1 | |
| SCHEMBL10579577 | 0.73 | SMN1; SMN2 (0.52) | DYRK1AGSK3BKDM4EALDH1A1MEN1 | |
| SCHEMBL25457958 | 0.69 | LMNA (0.35) | DYRK1AGSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL25562763 | 0.69 | GSK3B (0.34) | DYRK1AGSK3BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL25672326 | 0.69 | HTT (0.35) | DYRK1AGSK3BALDH1A1CLK2CLK3 | |
| SCHEMBL19393891 | 0.65 | TDP1 (0.41) | KDM4EALDH1A1MAPTTDP1SMN1; SMN2 | |
| SCHEMBL16632855 | 0.64 | ALOX15 (0.36) | DYRK1AGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018014800-A1 | CYCLOHEXYL BENZAMIDE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2018-01-25 | — | — | WO | disclosed |