Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808671 | 0.94 | PTPN5 (0.36) | RAPGEF4MAPTPTPN5GABRB3GABRA2 | |
| SCHEMBL19798776 | 0.88 | MAPT (0.34) | MAPTALOX12NPC1MAPK1RAB9A | |
| SCHEMBL19798778 | 0.71 | MAPT (0.34) | MAPTLMNATP53 | |
| SCHEMBL17356867 | 0.71 | MAPK1 (0.42) | MAPTNPC1MAPK1RAB9AKDM4E | |
| SCHEMBL17353592 | 0.67 | TP53 (0.47) | MAPTALOX12PTPN5NPC1MAPK1 | |
| SCHEMBL29865250 | 0.67 | TP53 (0.47) | MAPTALOX12PTPN5NPC1MAPK1 | |
| SCHEMBL22600834 | 0.64 | MAPT (0.32) | MAPTALOX12KDM4EALDH1A1 | |
| SCHEMBL19798774 | 0.64 | KDM1A (0.37) | MAPTALOX12NPC1RAB9AKDM4E | |
| SCHEMBL17356871 | 0.63 | MEN1 (0.40) | MAPTNPC1MAPK1RAB9AKDM4E | |
| SCHEMBL107119 | 0.62 | RAPGEF4 (0.56) | RAPGEF4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180026297-A1 | 1,9,10-SUBSTITUTED PHENATHIAZINE DERIVATIVES WITH STRAINED RADICAL CATIONS AND USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180026297-A1 | 1,9,10-SUBSTITUTED PHENATHIAZINE DERIVATIVES WITH STRAINED RADICAL CATIONS AND USE THEREOF | PFAS, SLC6A9, PEX3 | RAPGEF4 964/4885MAPT 4553/4885ALOX12 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.