Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11807089 | 0.76 | ATM (0.33) | ACACBKDM5A | |
| SCHEMBL11793334 | 0.75 | ALDH1A1 (0.42) | ACACBKDM5A | |
| SCHEMBL20095702 | 0.74 | — | — | |
| SCHEMBL19803240 | 0.73 | TRPV4 (0.34) | HTR1DAR | |
| SCHEMBL19505052 | 0.73 | TRPV4 (0.34) | AR | |
| SCHEMBL16097843 | 0.72 | KIF11 (0.38) | ACACBAR | |
| SCHEMBL21910149 | 0.71 | TTR (0.33) | KDM5A | |
| SCHEMBL21910189 | 0.70 | MPO (0.37) | KDM5A | |
| SCHEMBL25856446 | 0.70 | CYP11B1 (0.32) | AR | |
| SCHEMBL12724952 | 0.68 | TRPV4 (0.52) | HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180021316-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA PHARMACEUTICALS LP | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021316-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, TP53 | ACACB 1212/4885KDM5A 1547/4885HTR1D 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.