Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983301 | 0.91 | ALDH1A1 (0.45) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 | |
| SCHEMBL4958747 | 0.88 | ALDH1A1 (0.47) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 | |
| SCHEMBL15879913 | 0.76 | CHRM5 (0.46) | ALDH1A1CHRM5CHRM1CHRM3POLB | |
| SCHEMBL27805826 | 0.73 | OPRM1 (0.45) | ALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL20582129 | 0.73 | ALDH1A1 (0.49) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 | |
| SCHEMBL20400952 | 0.73 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1MAPK1SIGMAR1SLC6A2 | |
| SCHEMBL472086 | 0.71 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPK1SLC6A2SLC6A3 | |
| SCHEMBL19031238 | 0.71 | ALDH1A1 (0.46) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 | |
| SCHEMBL3991791 | 0.71 | ALDH1A1 (0.46) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 | |
| SCHEMBL3989535 | 0.70 | SIGMAR1 (0.45) | RORCALDH1A1L3MBTL1MAPK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512239-A1 | BRIDGED BICYCLIC RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075415-A1 | BRIDGED BICYCLIC RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-06-23 | — | — | WO | disclosed |