Sugi Predict

Sugi Predict / Compounds / SCHEMBL19805946

SCHEMBL19805946

SCHEMBL19805946

COc1ncc(-c2cc(C)nc(S)n2)cn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FTO Q9C0B1 3/20 0.41
▸ PIK3CA P42336 2/20 0.40
▸ MAPT P10636 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ ALKBH5 Q6P6C2 1/20 0.36
▸ DYRK1B Q9Y463 1/20 0.33
▸ TUBB4A P04350 1/20 0.33
▸ TUBB P07437 1/20 0.33
▸ TUBA3C P0DPH7 1/20 0.33
▸ TUBA1B P68363 1/20 0.33
▸ TUBA4A P68366 1/20 0.33
▸ TUBB4B P68371 1/20 0.33
▸ TUBB3 Q13509 1/20 0.33
▸ TUBB2A Q13885 1/20 0.33
▸ TUBB8 Q3ZCM7 1/20 0.33
▸ TUBA3E Q6PEY2 1/20 0.33
▸ TUBA1A Q71U36 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21019881 0.81 ALDH1A1 (0.41) FTOPIK3CAMAPTMEN1TSHR
SCHEMBL19806018 0.76 PIK3CA (0.47) PIK3CAMAPTMTORPDGFRBPDGFRA
SCHEMBL6844955 0.75 CYP1A1 (0.44) FTOPIK3CAALKBH5DYRK1BTUBB4A
SCHEMBL7524476 0.71 MEN1 (0.47) MAPTMEN1TSHRKMT2AATM
SCHEMBL13680586 0.70 CCR1 (0.52) FTOPIK3CAMAPTMEN1TSHR
SCHEMBL19806047 0.68 ALDH1A1 (0.44) MAPTKMT2A
SCHEMBL11752041 0.67 CYP1A2 (0.44) MAPTMEN1TSHRKMT2A
SCHEMBL51447 0.67 — —
SCHEMBL15345187 0.67 CCR1 (0.55) FTOPIK3CAMEN1KMT2AALKBH5
SCHEMBL19464686 0.66 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed
US-20210309647-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-10-07 — — US disclosed
US-11034680-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-06-15 — — US disclosed
US-20190152960-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-05-23 — — US disclosed
WO-2018014802-A1 APOPTOSIS INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2018-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152960-A1 Apoptosis Inhibitors BAX, SDHA, SDHB FTO 2431/4885PIK3CA 2807/4885MAPT 2304/4885
US-11725000-B2 Apoptosis inhibitors BAX, SDHA, SDHB FTO 2431/4885PIK3CA 2807/4885MAPT 2304/4885
US-11034680-B2 Apoptosis inhibitors BAX, SDHA, SDHB FTO 2431/4885PIK3CA 2807/4885MAPT 2304/4885
US-20210309647-A1 Apoptosis Inhibitors BAX, SDHA, SDHB FTO 2431/4885PIK3CA 2807/4885MAPT 2304/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.