Sugi Predict

Sugi Predict / Compounds / SCHEMBL19806047

SCHEMBL19806047

SCHEMBL19806047

COc1ccc(-c2cc(C)nc(S)n2)nn1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.44
▸ HTT P42858 2/20 0.44
▸ MAOB P27338 4/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ HSP90AA1 P07900 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ HIF1A Q16665 1/20 0.32
▸ NNMT P40261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19806046 0.80 ALDH1A1 (0.64) ALDH1A1HTTMAOBCYP1A2KMT2A
SCHEMBL1456221 0.75 NNMT (0.46) ALDH1A1HTTMAOBKMT2AKDM4E
SCHEMBL11752041 0.74 CYP1A2 (0.44) ALDH1A1HTTCYP1A2KMT2AKDM4E
SCHEMBL13052047 0.74 ALDH1A1 (0.42) ALDH1A1HTTMAOBCYP1A2KMT2A
SCHEMBL19805946 0.68 FTO (0.41) KMT2AMAPT
SCHEMBL51447 0.66 — —
SCHEMBL353814 0.66 NNMT (0.54) ALDH1A1HTTCYP1A2KMT2AKDM4E
SCHEMBL29795195 0.66 NNMT (0.54) ALDH1A1HTTCYP1A2KMT2AKDM4E
SCHEMBL7524476 0.66 MEN1 (0.47) ALDH1A1HTTKMT2AKDM4EMAPT
SCHEMBL1067804 0.65 LMNA (0.48) ALDH1A1HTTCYP1A2KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed
US-20210309647-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-10-07 — — US disclosed
US-11034680-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-06-15 — — US disclosed
EP-3484854-B1 APOPTOSIS INHIBITORS NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) 2021-01-20 — — EP disclosed
US-20190152960-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-05-23 — — US disclosed
WO-2018014802-A1 APOPTOSIS INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2018-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152960-A1 Apoptosis Inhibitors BAX, SDHA, SDHB ALDH1A1 550/4885HTT 788/4885MAOB 585/4885
US-11725000-B2 Apoptosis inhibitors BAX, SDHA, SDHB ALDH1A1 550/4885HTT 788/4885MAOB 585/4885
US-11034680-B2 Apoptosis inhibitors BAX, SDHA, SDHB ALDH1A1 550/4885HTT 788/4885MAOB 585/4885
US-20210309647-A1 Apoptosis Inhibitors BAX, SDHA, SDHB ALDH1A1 550/4885HTT 788/4885MAOB 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.