Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 12/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019760 | 0.92 | SDHB (0.40) | SDHBTP53SMN1; SMN2GAAMAPT | |
| SCHEMBL21020127 | 0.87 | SDHB (0.40) | SDHBTP53SMN1; SMN2GAAMAPT | |
| SCHEMBL21019476 | 0.87 | SDHB (0.39) | SDHBTP53SMN1; SMN2GAAMAPT | |
| SCHEMBL22912258 | 0.86 | MAPT (0.41) | TP53SMN1; SMN2GAAMAPTMAPK10 | |
| SCHEMBL21019919 | 0.85 | TP53 (0.36) | SDHBTP53HIF1APOLB | |
| SCHEMBL23897419 | 0.83 | SDHB (0.41) | SDHBTP53SMN1; SMN2GAAMAPT | |
| SCHEMBL26312805 | 0.83 | SDHB (0.54) | SDHBTP53SMN1; SMN2GAAMAPT | |
| SCHEMBL26312785 | 0.82 | SDHB (0.41) | SDHBMAPK10HIF1A | |
| SCHEMBL21019920 | 0.82 | TP53 (0.35) | SDHBTP53MAPK10HIF1A | |
| SCHEMBL21020130 | 0.81 | ALDH1A1 (0.35) | SDHBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | SDHB 3/4885TP53 160/4885SMN1; SMN2 1698/4885 |
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | SDHB 3/4885TP53 160/4885SMN1; SMN2 1698/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | SDHB 3/4885TP53 160/4885SMN1; SMN2 1698/4885 |
| US-20210309647-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | SDHB 3/4885TP53 160/4885SMN1; SMN2 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.