Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | TP53 | P04637 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806037 | 0.83 | SDHB (1.00) | SDHBMAPTTP53GAAKDM4E | |
| SCHEMBL19805762 | 0.82 | MAPT (0.63) | MAPTTP53POLBKDM4ESMN1; SMN2 | |
| SCHEMBL22912267 | 0.79 | KDM4E (0.64) | MAPTPOLBKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19805711 | 0.76 | ALDH1A1 (0.71) | SDHBMAPTPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6722321 | 0.74 | KDM4E (0.72) | MAPTPOLBKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL22912240 | 0.74 | KDM4E (0.67) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL15390518 | 0.72 | KDM4E (1.00) | MAPTTP53GAAPOLBKDM4E | |
| SCHEMBL19805735 | 0.72 | KDM4E (0.66) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL19805915 | 0.70 | KDM4E (0.66) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL19805734 | 0.68 | KDM4E (0.60) | SDHBMAPTTP53POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |