Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | PCNA | P12004 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980615 | 0.88 | CNR2 (0.38) | CNR2KMT2ASCN9ASLC6A2SLC6A4 | |
| SCHEMBL1971789 | 0.76 | MEN1 (0.40) | KMT2AADAM17 | |
| SCHEMBL1970202 | 0.75 | ALDH1A1 (0.40) | KMT2ASMN1; SMN2NPC1RAB9APOLB | |
| Hydrochloric Acid SCHEMBL2811108 | 0.74 | ALDH1A1 (0.39) | KMT2ASMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL5479901 | 0.74 | GRIA2 (0.39) | CNR2KMT2ASCN9ASLC6A2SLC6A4 | |
| SCHEMBL5479955 | 0.74 | GRIA2 (0.39) | CNR2KMT2ASCN9ASLC6A2SLC6A4 | |
| SCHEMBL5481528 | 0.74 | GRIA2 (0.39) | CNR2KMT2ASCN9ASLC6A2SLC6A4 | |
| SCHEMBL1969375 | 0.73 | LMNA (0.38) | SMN1; SMN2HTTKDM4ETSHR | |
| SCHEMBL760930 | 0.73 | TDP1 (0.41) | KMT2ASMN1; SMN2HTTKDM4EPOLB | |
| SCHEMBL1970213 | 0.71 | MMP3 (0.41) | SMN1; SMN2HTTNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236790-B2 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATORIES SERVIER (FR) | 2012-08-07 | — | — | US | disclosed |
| EP-2246339-B1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | SERVIER LAB (FR) | 2011-06-22 | — | — | EP | disclosed |
| EP-2246339-A1 | Derivatives of benzothiazepine and their use as modulators of AMPA and NMDA receptors | Les Laboratoires Servier (FR) | 2010-11-03 | — | — | EP | disclosed |
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240635-A1 | Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them | GRIN1, GRIN2B, GRIN3A | CNR2 37/4885KMT2A 353/4885SCN9A 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.