Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806682 | 0.84 | RAB9A (0.58) | RAB9AHDAC6LMNAALDH1A1MAPK14 | |
| SCHEMBL30572262 | 0.84 | CCNE2 (0.48) | RAB9ALMNAALDH1A1MAPK14KDM4E | |
| SCHEMBL25222404 | 0.74 | MAPK1 (0.53) | RAB9AMAPK1MEN1KMT2A | |
| SCHEMBL24867506 | 0.74 | MAPK14 (0.50) | HDAC6LMNAMAPK14MAPK1 | |
| SCHEMBL25258204 | 0.74 | DHODH (0.46) | RAB9ALMNAMAPK14KDM4EHPGD | |
| SCHEMBL5317383 | 0.74 | HDAC6 (0.56) | RAB9AHDAC6LMNAALDH1A1MAPK14 | |
| SCHEMBL14114505 | 0.73 | SMN1; SMN2 (0.41) | RAB9AHDAC6LMNAAHRSMN1; SMN2 | |
| SCHEMBL25267837 | 0.73 | RAB9A (0.44) | RAB9AALDH1A1NPC1SMN1; SMN2MAPK1 | |
| SCHEMBL24867343 | 0.72 | PTGDR2 (0.40) | HDAC6MAPK14MAPK1POLBDYRK1A | |
| SCHEMBL25210468 | 0.72 | ALDH1A1 (0.47) | HDAC6ALDH1A1KDM4ESMN1; SMN2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018017633-A1 | TGF Beta RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-25 | — | — | WO | disclosed |