Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328841 | 0.77 | POLB (0.43) | MAOBMAOASLC6A2SLC6A3KDM1A | |
| SCHEMBL18383187 | 0.77 | POLB (0.43) | MAOBMAOASLC6A2SLC6A3KDM1A | |
| SCHEMBL3832964 | 0.77 | KDM1A (0.37) | MAOBMAOASLC6A2SLC6A3ATM | |
| SCHEMBL18383190 | 0.77 | POLB (0.43) | MAOBMAOASLC6A2SLC6A3KDM1A | |
| SCHEMBL3530476 | 0.75 | SIRT1 (0.41) | SLC6A2SLC6A3ATMCYP2C9NISCH | |
| SCHEMBL14071736 | 0.74 | MAOB (0.45) | MAOBMAOASLC6A2SLC6A3KDM1A | |
| SCHEMBL1582078 | 0.74 | ADRA1A (0.42) | MAOBMAOA | |
| SCHEMBL27734696 | 0.74 | KDM4E (0.38) | MAOBMAOASLC6A2SLC6A3ATM | |
| SCHEMBL10764252 | 0.73 | MAOA (0.41) | MAOBMAOAATMGUSBKDM1A | |
| SCHEMBL28513561 | 0.73 | HTR2C (0.37) | SLC6A2SLC6A3KDM1ASLC6A4KDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102770413-B | 5-amino-4-hydroxy-pentanoylamides | JANSSEN R&D IRELAND (IE) | 2015-08-26 | — | — | CN | disclosed |
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| US-8592429-B2 | 5-amino-4-hydroxypentoyl amides | JANSSEN R&D IRELAND (IE) | 2013-11-26 | — | — | US | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
| CN-102770413-A | 5-amino-4-hydroxy-pentanoylamides | TIBOTEC PHARM LTD | 2012-11-07 | — | — | CN | disclosed |
| EP-2509950-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | Janssen R&D Ireland (IE) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070131-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-16 | — | — | WO | disclosed |
| EP-0091748-B1 | ANTIHYPERTENSIVE BENZOPYRANOLS | BEECHAM GROUP PLC (GB) | 1986-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | C1S, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-10 | MAOB 3037/4885MAOA 2732/4885SLC6A2 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.