Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 12/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18003627 | 0.77 | PIK3CA (0.52) | PIK3CAKCNH2PIK3CDPIK3CBPI4KA | |
| SCHEMBL9607467 | 0.77 | DGAT1 (0.42) | KCNH2TRPV3 | |
| SCHEMBL12537989 | 0.77 | TRPV3 (0.50) | KCNH2TRPV3 | |
| SCHEMBL12537909 | 0.75 | TRPV3 (0.49) | KCNH2TRPV3 | |
| SCHEMBL12539149 | 0.75 | TRPV3 (0.50) | KCNH2TRPV3 | |
| SCHEMBL18003520 | 0.75 | PIK3CA (0.50) | PIK3CAKCNH2PIK3CDPIK3CBPI4KA | |
| SCHEMBL12538603 | 0.75 | TRPV3 (0.46) | KCNH2TRPV3 | |
| SCHEMBL18003021 | 0.74 | KIF11 (0.47) | PIK3CAKCNH2PIK3CDPIK3CBPI4KA | |
| SCHEMBL12615461 | 0.74 | TRPV3 (0.48) | KCNH2TRPV3 | |
| SCHEMBL16635088 | 0.73 | HDAC1 (0.44) | PIK3CAKCNH2PIK3CDPIK3CBPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015411-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |