Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979949 | 0.91 | PDK1 (0.43) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL1980046 | 0.86 | HTR2C (0.43) | MEN1KMT2AGAARAB9ALMNA | |
| SCHEMBL1980030 | 0.85 | MTNR1B (0.61) | PDK1PDK2PDK3PDK4MTNR1B | |
| SCHEMBL1980442 | 0.80 | MAPT (0.42) | MEN1KMT2AHTTGAARAB9A | |
| SCHEMBL1981045 | 0.76 | MTNR1B (0.41) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL13832459 | 0.74 | MTNR1B (0.52) | MEN1KMT2AMTNR1BMTNR1AHTT | |
| SCHEMBL1979299 | 0.74 | MTNR1B (0.52) | MEN1KMT2AMTNR1BMTNR1APGR | |
| SCHEMBL1983453 | 0.73 | ALDH1A1 (0.42) | MEN1KMT2ARAB9ALMNAMAPT | |
| SCHEMBL13720664 | 0.73 | MTNR1B (0.46) | MEN1KMT2AMTNR1BMTNR1APGR | |
| SCHEMBL1978265 | 0.73 | XIAP (0.58) | MTNR1BMTNR1APGRHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509961-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | Autifony Therapeutics Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069951-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |