Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16232168 | 0.78 | MMP2 (0.50) | MMP2MMP7MMP14HSD11B1 | |
| SCHEMBL776801 | 0.77 | AKR1B1 (0.44) | CA2AKR1B1CCR2KCNH2 | |
| SCHEMBL23358180 | 0.76 | AKR1B1 (0.42) | CES2CES1CA2AKR1B1CCR2 | |
| SCHEMBL29986069 | 0.74 | TAS1R3 (0.50) | LMNA | |
| SCHEMBL24816196 | 0.74 | TAS1R3 (0.50) | LMNA | |
| SCHEMBL10203496 | 0.73 | MMP2 (0.63) | CA2MMP2MMP7MMP14HSD11B1 | |
| SCHEMBL776555 | 0.73 | AKR1B1 (0.41) | CES2CES1CA2AKR1B1CCR2 | |
| SCHEMBL4175553 | 0.73 | CA2 (0.45) | CES2CES1CA2AKR1B1CCR2 | |
| SCHEMBL29391243 | 0.73 | AKR1B1 (0.41) | CES2CES1CA2AKR1B1LMNA | |
| SCHEMBL795339 | 0.72 | AKR1B1 (0.46) | CES2CES1AKR1B1CA9CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-25 | — | — | US | disclosed |
| EP-2512250-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | Temple University - Of The Commonwealth System of Higher Education (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075616-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | MKI67, CCNA1, FOLR1 | CES2 4040/4885CES1 2465/4885TBXA2R 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.