Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPD | P32754 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1981364 | 0.89 | SCN9A (0.41) | HDAC1HDAC8HDAC6ALOX15SCN9A | |
| SCHEMBL27691782 | 0.84 | SRD5A1 (0.35) | ALDH1A1NPSR1HDAC1HDAC8HDAC6 | |
| SCHEMBL3094367 | 0.83 | RHEB (0.37) | ALDH1A1NPSR1HDAC1HDAC8HDAC6 | |
| SCHEMBL1955922 | 0.83 | L3MBTL1 (0.48) | ALDH1A1SMN1; SMN2L3MBTL1SCN9AHPD | |
| SCHEMBL14735729 | 0.82 | PRKCA (0.39) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 | |
| SCHEMBL1980568 | 0.82 | PRKCA (0.39) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 | |
| SCHEMBL3098417 | 0.82 | ALDH1A1 (0.37) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 | |
| SCHEMBL5443997 | 0.80 | ALDH1A1 (0.39) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 | |
| SCHEMBL27967737 | 0.78 | SCN9A (0.37) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 | |
| SCHEMBL391724 | 0.78 | ALDH1A1 (0.41) | ALDH1A1ATMSMN1; SMN2NPSR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331554-B1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | JANSSEN R & D IRELAND (IE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2331554-B1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | JANSSEN R & D IRELAND (IE) | 2013-03-06 | — | — | EP | disclosed |
| US-8357687-B2 | Macrocyclic indole derivatives useful as hepatitis C virus inhibitors | TIBOTEC PHARMACEUTICALS (IE) | 2013-01-22 | — | — | US | disclosed |
| US-8357687-B2 | Macrocyclic indole derivatives useful as hepatitis C virus inhibitors | TIBOTEC PHARMACEUTICALS (IE) | 2013-01-22 | — | — | US | disclosed |
| US-8357687-B2 | Macrocyclic indole derivatives useful as hepatitis C virus inhibitors | TIBOTEC PHARMACEUTICALS (IE) | 2013-01-22 | — | — | US | disclosed |
| CN-102124012-A | Macrocyclic indole derivatives useful as hepatitis C virus inhibitors | TIBOTEC PHARM LTD | 2011-07-13 | — | — | CN | disclosed |
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-23 | — | — | US | disclosed |
| WO-2010018233-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS (IE) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152279-A1 | MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS | IDO1, IDO2, ZC3HAV1 | ALDH1A1 1544/4885ATM 3593/4885SMN1; SMN2 4725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.