Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30117430 | 0.83 | TGFBR1 (0.58) | TGFBR1 | |
| SCHEMBL15639428 | 0.83 | TGFBR1 (0.58) | TGFBR1 | |
| SCHEMBL15640075 | 0.80 | ACVR1 (0.37) | TGFBR1NOTUMKCNH2LRRK2ACVR1 | |
| SCHEMBL19817535 | 0.77 | TGFBR1 (0.51) | TGFBR1METAP2GRIN1GRIN2BKMO | |
| SCHEMBL15638472 | 0.76 | ACVR1 (0.39) | TGFBR1NOTUMKCNH2LRRK2ACVR1 | |
| SCHEMBL30117442 | 0.75 | TGFBR1 (0.41) | TGFBR1NOTUMKCNH2LRRK2ABL1 | |
| SCHEMBL15638995 | 0.75 | QPCT (0.47) | TGFBR1LRRK2ACVR1 | |
| SCHEMBL15639216 | 0.75 | TGFBR1 (0.41) | TGFBR1NOTUMKCNH2LRRK2ABL1 | |
| SCHEMBL15638873 | 0.73 | TGFBR1 (0.52) | TGFBR1NOTUMKCNH2NMT1 | |
| SCHEMBL28019359 | 0.73 | KCNH2 (0.46) | NOTUMKCNH2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878992-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-01-30 | — | — | US | disclosed |